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How Long Does Compounded Semaglutide Last in the Fridge?

How Long Does Compounded Semaglutide Last in the Fridge?

When your medication package arrives at your home, it’s a very exciting moment. It is the first step on your new health journey. As you open the cold-packed box, keeping your new medicine safe and effective becomes your top priority. You already know that your semaglutide belongs in the fridge. But that leads to another very important question that you might be thinking about: just how long is it good for? This is a very smart question to ask. So, how long does compounded semaglutide last in the fridge?

The Most Important Date: Your “Beyond-Use Date” (BUD)

When you buy food at the grocery store, you look for an “expiration date.” This is the date the factory printed on the box to tell you when the food is no longer fresh.

Compounded medicines are a little different. They don’t have a factory expiration date. Instead, they have something that is even more important. It is called a “Beyond-Use Date,” or you can just call it the BUD.

The BUD is a special date that the compounding pharmacy puts on the label of your medicine vial. This date tells you the last day that the pharmacy can promise that your medicine is perfectly safe and has its full power. This is the most important date to pay attention to when you are learning how to store compounded semaglutide.

So, How Long Does Compounded Semaglutide Last in the Fridge?

This is the big question, and the answer is that you must always look at the label on your own vial of medicine. The exact BUD is decided by the compounding pharmacy. They follow very strict rules to figure out the right date for each batch of medicine they make.

In most cases, the Beyond-Use Date for compounded semaglutide is usually between 28 and 56 days from the date that the pharmacy mixed it for you. But you must always check your own label to be sure.

The label on your vial is the only true answer to how long does compounded semaglutide last in the fridge. It is the most important piece of information for your safety. We know this is important, and our commitment is to partner with high-quality U.S. pharmacies that follow these strict rules.

Why is the Beyond-Use Date So Strict?

You might be wondering why you have to be so careful about this one date. Following the BUD is very important for two big reasons: keeping the medicine powerful and keeping the medicine safe.

It Loses Its Power (Potency)

As we’ve talked about before, semaglutide is a very delicate medicine. Think of it like a fragile flower. Even when you keep a flower in a vase of water in a cool room, it will naturally start to wilt over time.

Your medication is similar. Even when it is kept perfectly in the fridge, it will naturally start to break down a little bit over time. The BUD is set to make sure that you use the medicine while it is still 100% powerful. After that date, it might not be strong enough to work as well as it should.

It Could Become Unsafe (Sterility)

This is the most important reason to follow the semaglutide beyond its use date. When a compounding pharmacy makes your medicine, they mix it in a super clean, special room called a clean room. This is to make sure there are no germs in your medicine when you get it.

But compounded medicines do not have the same strong, long-lasting preservatives that factory-made medicines do. The BUD is also there to make sure that your medicine stays sterile and that no harmful bacteria have a chance to grow inside the vial. This is the key to your compounded semaglutide expiration and safety.

Best Practices for Storing Your Medication

Following the BUD is rule number one. Here are a few more easy tips to make sure you are storing your medicine perfectly every time.

1. Keep it Cold, Not Frozen

As soon as you get your medicine, put it on a middle shelf of your fridge. Try not to keep it in the door, where the temperature goes up and down. Also, don’t push it to the very back of the fridge, where it might accidentally freeze and get ruined.

2. Keep it in the Dark

The box your medicine comes in is important. It helps to protect the delicate medicine from the light inside your fridge. Always keep the vial inside its original box for extra protection.

3. Check the Vial Before Every Use

Every time you get ready to take your dose, take a quick look at the vial. The liquid inside should be clear and look like water. If you ever see that the liquid is cloudy, has little specks floating in it, or has changed color, do not use it.

Your health journey should always be safe. A safe and effective journey starts with a free medical consultation.

A Simple and Supportive Path to Your Health Goals

We want you to feel completely confident in every part of your treatment. That includes feeling sure that your medication is fresh and safe, and also knowing exactly what your treatment will cost.

Our all-inclusive program is $299 per month. This one price covers your ongoing medical care, your medication, which is always freshly compounded just for you, all of your supplies, and special cold-packed shipping right to your door.

We believe in supporting you every step of the way. If you ever have a question about your medication, you can always ask questions about your medication’s BUD through the Patient Portal.

The Final Answer on Your Medication’s Shelf Life

So, let’s bring it all together for one final, simple answer.

The question “how long does compounded semaglutide last in the fridge” has one very clear and very important rule: you must always follow the Beyond-Use Date that is printed on the label of your vial.

Respecting this date and throwing away any unused medicine after this date is the most important thing you can do. It makes sure that your treatment is both safe and effective every single time you use it.

If you have any more questions about the safety of your medication, our friendly team is always here to help. Please contact our friendly team if you have any more questions about safety.

Sources and Further Reading:

For readers who wish to learn more from official sources, we recommend the following resources. These are non-competing, authoritative links that provide additional information on this topic.

  1. U.S. Pharmacopeia (USP) – “General Chapter <797> Pharmaceutical Compounding—Sterile Preparations”: https://www.usp.org/compounding/general-chapter-797 (The official source for the rules pharmacies follow for BUDs).
  2. U.S. Food and Drug Administration (FDA) – “Compounding and the FDA: Questions and Answers”: https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers
Dr. Concetta Green, MD – Board-Certified in Internal Medicine, brings over 12 years of expertise in endocrinology and personalized weight management to help patients achieve lasting health and wellness. Specializing in modern, evidence-based approaches, including GLP-1 medications, Dr. Green guides individuals toward their health goals safely and effectively. Her compassionate care and personalized strategies empower patients to take control of their wellness journey and embrace sustainable lifestyle changes.

Sources

  • Official Patient Guide for Wegovy (semaglutide) Injections: Confirms acceptable injection sites (abdomen, thigh, upper arm), advises keeping injections at least two inches away from the belly button, and provides site hygiene and general device instructions. [Wegovy Patient Guide]
  • Novo Nordisk Professional Administration Guide (Wegovy): Details the subcutaneous route into the abdomen, thigh, or upper arm, and advises patients to rotate injection sites. [novoMEDLINK]
  • Wegovy Prescribing Information (U.S.): Notes that timing of day and injection site may be changed without dose adjustment; treatment should be administered once weekly on the same day. [Wegovy Prescribing Info]
  • Ozempic (semaglutide) – “How to Take” Guide: Reinforces injection site rotation; if using the same area, select a different spot each time. [Ozempic Guide]
  • Peer-Reviewed Literature on Lipohypertrophy and Injection Rotation: Explains how consistently rotating sites and spacing injections may lower the risk of lipohypertrophy and improve medication absorption. [PubMed Central]

Important Medical Information and Disclaimers

Medical Disclaimer

This content is for educational purposes only and should not be considered medical advice, diagnosis, or treatment guidance. The U.S. Food and Drug Administration (FDA) has not approved compounded semaglutide for weight management or any other use. Now that the national shortage has ended, federal law generally prohibits pharmacies from compounding products that are essentially copies of FDA-approved medications such as Wegovy. Compounded semaglutide may carry risks related to safety, quality, and dosing accuracy because it does not undergo FDA review for safety, effectiveness, or manufacturing standards. Always consult a qualified healthcare provider before starting or continuing any semaglutide treatment, and obtain prescriptions only for FDA-approved medications dispensed through licensed pharmacies.

Individual Results May Vary

Weight management outcomes with semaglutide can differ significantly from person to person. Clinical trial data may not predict real-world experiences. Factors that influence results include:

  • Consistency with prescribed medication use
  • Dietary habits and exercise routines
  • Metabolic differences
  • Other underlying health conditions
  • Concurrent medications

No specific outcome or result can be guaranteed.

Important Safety Information

The most commonly reported side effects of semaglutide include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Stomach pain
  • Decreased appetite
  • Indigestion
  • Belching or gas
  • Injection site reactions

These side effects are often mild and may lessen over time. Before starting semaglutide, inform your healthcare provider about all medical conditions, allergies, and medications you are currently taking. Ongoing clinical monitoring is recommended during treatment.

Warning: Semaglutide carries a boxed warning regarding the potential risk of thyroid C‑cell tumors. Do not use semaglutide if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Adverse Event Reporting

If you experience negative side effects from any prescription medication, you are encouraged to report them to the U.S. Food and Drug Administration (FDA) through the MedWatch Adverse Event Reporting Program or by calling 1-800-332-1088. Adverse events may also be reported directly to the medication manufacturer.

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