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Does Semaglutide Expire After 28 Days

Does Semaglutide Expire After 28 Days?

When you start a new health journey, it’s smart to know how to handle your medication the right way. Using a helpful treatment like Semaglutide means that storing it correctly is very important for your safety and for getting the best results. You might be looking at your medicine and asking, does semaglutide expire after 28 days? That’s a great question, and the answer is not always a simple yes or no.

It really depends on which type of Semaglutide you are using. This guide will give you the clear answers you need to feel confident and safe.

The 56-Day Rule: Expiration for Branded Pens (Ozempic & Wegovy)

First, let’s talk about the well-known brand-name pens, like Ozempic and Wegovy. These come in pre-filled pens that are sealed by the company that makes them.

For these specific pens, the rule is actually 56 days. That means after you use a pen for the first time, you can continue to use it for up to 56 days, or 8 weeks.

This is the official Ozempic pen expiration and Wegovy expiration after opening rule from the manufacturer. Just make sure you are storing it correctly during that time.

The 28-Day Rule: Understanding Compounded Semaglutide

Now, let’s talk about a different form of this medication. This is where the 28-day rule usually comes into play.

What is Compounded Semaglutide?

Sometimes, a special kind of pharmacy, called a compounding pharmacy, prepares medication specifically for a patient. This is called compounded Semaglutide. It usually comes in a small glass bottle, called a vial, instead of a pre-filled pen.

Why the Shorter Expiration Date?

This is the most important part to understand. The question “does semaglutide expire after 28 days” is most often about these compounded vials. The reason for the shorter time is all about keeping you safe.

Compounded medicines have something called a “Beyond-Use Date,” or BUD. Think of it like an expiration date for your safety. Each time you take a dose, you have to put a new, clean needle through the vial’s rubber stopper.

Even when you are very careful, doing this over and over can create a tiny risk of germs getting inside. To make sure the medicine stays perfectly clean and safe, these vials have a shorter life. The special ingredients that keep it sterile, called preservatives, only work for a limited time. This compounded semaglutide shelf life is often 28 days to be extra safe.

Why You Should Never Use Expired Semaglutide

It can be tempting to use medication past its expiration date, but it’s a bad idea. There are two big risks when it comes to using expired semaglutide.

First, it might not work anymore. Over time, the medicine inside can start to break down. This means it gets weaker, and you won’t get the full benefit from your dose.

Second, and most importantly, it could be unsafe. After the expiration date or BUD, especially with a vial you’ve been using, there is a small chance that bacteria could start to grow inside. This could make you very sick if you inject it. Your health is not worth the risk.

How to Store Semaglutide Correctly: A Step-by-Step Guide

Knowing how to store semaglutide is easy once you know the rules. It helps keep your medicine safe and effective from the first dose to the last.

Before Your First Use

Before you use your Semaglutide for the very first time, it should be kept in the refrigerator. Be careful not to let it freeze! A frozen vial or pen should be thrown away.

After Your First Use

This is where the rules can change a little bit.

  • Branded Pens: After your first use, you can keep your pen in the fridge or at room temperature for up to 56 days. Just make sure it doesn’t get too hot.

  • Compounded Vials: It’s usually best to keep these in the refrigerator even after you start using them. Always follow the specific instructions that come from your pharmacy.

Also, always keep your medication out of direct sunlight. Heat and light are enemies of many medicines and can make them break down faster.

Your Partner in Safe and Effective Treatment

Managing your treatment is about more than just taking the medicine. It’s also about understanding how to use it safely and correctly every single day.

Our commitment to patient safety means we provide you with all the information you need for a successful journey. We make sure you know exactly how to handle your specific medication.

Imagine Sarah looking at her vial. The label clearly says to discard it 28 days after the first use. By following this simple instruction from her provider, she knows that every dose she takes is both safe and fully effective.

Our streamlined program at Semaglutide Medics is designed for peace of mind, costing a flat rate of $299 per month. This fee is all-inclusive, covering your medical consultations, prescription medication, and convenient, free delivery right to your door.

This ensures you always have a fresh, effective supply of medication when you need it, and you can manage it all through your secure patient portal.

Conclusion: So, Does Semaglutide Expire After 28 Days?

So, let’s answer our question one last time. The answer to whether does semaglutide expire after 28 days really depends on what kind you have. For compounded vials, the answer is often yes, for your safety. For branded pens, you have a longer time of 56 days.

The most important takeaway is simple: always read the label on your medicine. Follow the storage and expiration instructions from your doctor or pharmacist.

Your safety is the number one priority. If you’re ever unsure about your medication, it’s always best to ask an expert. Contact our dedicated support team with any questions you have.

Sources:

Dr. Concetta Green, MD – Board-Certified in Internal Medicine, brings over 12 years of expertise in endocrinology and personalized weight management to help patients achieve lasting health and wellness. Specializing in modern, evidence-based approaches, including GLP-1 medications, Dr. Green guides individuals toward their health goals safely and effectively. Her compassionate care and personalized strategies empower patients to take control of their wellness journey and embrace sustainable lifestyle changes.

Sources

  • Official Patient Guide for Wegovy (semaglutide) Injections: Confirms acceptable injection sites (abdomen, thigh, upper arm), advises keeping injections at least two inches away from the belly button, and provides site hygiene and general device instructions. [Wegovy Patient Guide]
  • Novo Nordisk Professional Administration Guide (Wegovy): Details the subcutaneous route into the abdomen, thigh, or upper arm, and advises patients to rotate injection sites. [novoMEDLINK]
  • Wegovy Prescribing Information (U.S.): Notes that timing of day and injection site may be changed without dose adjustment; treatment should be administered once weekly on the same day. [Wegovy Prescribing Info]
  • Ozempic (semaglutide) – “How to Take” Guide: Reinforces injection site rotation; if using the same area, select a different spot each time. [Ozempic Guide]
  • Peer-Reviewed Literature on Lipohypertrophy and Injection Rotation: Explains how consistently rotating sites and spacing injections may lower the risk of lipohypertrophy and improve medication absorption. [PubMed Central]

Important Medical Information and Disclaimers

Medical Disclaimer

This content is for educational purposes only and should not be considered medical advice, diagnosis, or treatment guidance. The U.S. Food and Drug Administration (FDA) has not approved compounded semaglutide for weight management or any other use. Now that the national shortage has ended, federal law generally prohibits pharmacies from compounding products that are essentially copies of FDA-approved medications such as Wegovy. Compounded semaglutide may carry risks related to safety, quality, and dosing accuracy because it does not undergo FDA review for safety, effectiveness, or manufacturing standards. Always consult a qualified healthcare provider before starting or continuing any semaglutide treatment, and obtain prescriptions only for FDA-approved medications dispensed through licensed pharmacies.

Individual Results May Vary

Weight management outcomes with semaglutide can differ significantly from person to person. Clinical trial data may not predict real-world experiences. Factors that influence results include:

  • Consistency with prescribed medication use
  • Dietary habits and exercise routines
  • Metabolic differences
  • Other underlying health conditions
  • Concurrent medications

No specific outcome or result can be guaranteed.

Important Safety Information

The most commonly reported side effects of semaglutide include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Stomach pain
  • Decreased appetite
  • Indigestion
  • Belching or gas
  • Injection site reactions

These side effects are often mild and may lessen over time. Before starting semaglutide, inform your healthcare provider about all medical conditions, allergies, and medications you are currently taking. Ongoing clinical monitoring is recommended during treatment.

Warning: Semaglutide carries a boxed warning regarding the potential risk of thyroid C‑cell tumors. Do not use semaglutide if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Adverse Event Reporting

If you experience negative side effects from any prescription medication, you are encouraged to report them to the U.S. Food and Drug Administration (FDA) through the MedWatch Adverse Event Reporting Program or by calling 1-800-332-1088. Adverse events may also be reported directly to the medication manufacturer.

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